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Sharon Lubkin, NC State, Surprises from modeling lung development
April 12, 2018 | 4:30 pm - 5:30 pm EDT
Tissues grow, change shape, and differentiate, function normally or abnormally, get diseased or injured, repair themselves, and sometimes
atrophy. This complex suite of behaviors is governed by a complex suite of controls. Nonetheless, we can identify some general principles at work in the dynamics of tissues. Our goal is to understand how a tissues mechanics and biology regulate each other. An important and complex organ like the lung doesn’t just show up fully formed. How does it get there? What controls the development from a relatively simple blob of cells? Our models use biologically-based continuum mechanics to track the component cells, fluids, signaling molecules,
and extracellular matrix materials. The presentation will describe our modeling approach, reveal some of the general principles we have identified, and discuss some of our findings about early development of the lung.
atrophy. This complex suite of behaviors is governed by a complex suite of controls. Nonetheless, we can identify some general principles at work in the dynamics of tissues. Our goal is to understand how a tissues mechanics and biology regulate each other. An important and complex organ like the lung doesn’t just show up fully formed. How does it get there? What controls the development from a relatively simple blob of cells? Our models use biologically-based continuum mechanics to track the component cells, fluids, signaling molecules,
and extracellular matrix materials. The presentation will describe our modeling approach, reveal some of the general principles we have identified, and discuss some of our findings about early development of the lung.