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Biomathematics Seminar: Xingcheng Lin, Genome Organization from the Ground Up – Deciphering Molecular Mechanisms for Chromatin Organization

Cox 306

Chromatin structure tightly regulates gene expression and epigenetic processes. The nuclear environment is complex, featuring tension exerted by force-generating proteins and molecular crowding modulated by different ionic concentrations. Understanding the impact of these factors on chromatin structure is crucial for elucidating the molecular mechanisms of chromatin accessibility and organization. However, it is unclear how chromatin…

Biomathematics Seminar: Yutong Sha, University of California Irvine, Reconstructing transition dynamics from static single-cell genomic data

Cox 306

Recently, single-cell transcriptomics has provided a powerful approach to investigate cellular properties in unprecedented resolution. However, given a small number of temporal snapshots of single-cell transcriptomics, how to connect them to obtain their collective dynamical information remains an unexplored area. One major challenge to connecting temporal snapshots is that cells measured at one temporal point…

Biomathematics Seminar: TBA

Cox 306

All BMA seminars have a virtual option with the following Zoom Link: https://ncsu.zoom.us/j/93046132033?pwd=dkZiTjlKazgzK2Q3aXJra1g2R1Q0dz09 Meeting ID: 930 4613 2033 Passcode: 075251

Biomathematics Seminar: Kyle Nguyen, NC State

Cox 306

All BMA seminars have a virtual option with the following Zoom Link: https://ncsu.zoom.us/j/93046132033?pwd=dkZiTjlKazgzK2Q3aXJra1g2R1Q0dz09 Meeting ID: 930 4613 2033 Passcode: 075251

Biomath Seminar: Siting Liu, UCLA, An inverse problem in mean field game from partial boundary measurement

Cox 306

Mean-field game (MFG) systems provide a powerful framework for modeling the collective behavior of multi-agent systems with diverse applications, including those in biological populations. However, unknown parameters pose challenges. In this work, we tackle an inverse problem, recovering MFG parameters from limited, noisy boundary observations. Despite the problem's ill-posed nature, we aim to efficiently retrieve…

Biomathematics Seminar: Justin Lessler, UNC, What are planning scenarios for and how can we evaluate them?

Cox 306

As with weather, there is a limit to how far into the future we can accurately forecast the future course of epidemics. Yet, we often need to make plans further into the future than we can reasonably forecast, and in many cases our actions themselves will change the course of an epidemic. One solution to this conundrum is the construction of "planning scenarios" where we project the likely course of an epidemic well beyond the…

Biomathematics Seminar: Caroline Moosmueller, UNC, Optimal transport for point-cloud data analysis with applications in biology

Cox 306

This talk will focus on point-cloud data, their analysis and biological applications in which they naturally arise. In particular, I will introduce "optimal transport", which has evolved as one of the major frameworks to meaningfully compare point-cloud data and explain how it can be incorporated into classical machine learning algorithms for further downstream analysis. This…

Biomathematics Seminar: Jichun Xie, Duke, Disentangling Cellular Heterogeneities and Activities from the Topology Structures of Single-cell Co-expression Graphs

Cox 306

Gene co-expression graphs are a rich source of information, revealing critical insights into cellular functions, states, and activities. Yet, extracting meaningful signals from these graphs presents a formidable challenge. This complexity arises due to the presence of multiple, overlapping sources of information and the inherent noise, which is particularly pronounced in data derived from single-cell…