Generalizing unknotting number, n-adjacent knots have n crossings such that changing any non-empty subset of them results in the unknot. We determine the 2-adjacent knots through 12-crossings, with one exception. Using Heegaard Floer d-invariants and the Alexander polynomial, we develop a new technique to obstruct 2-adjacency, and we prove conjectures of Ito and Kato regarding 2-adjacent knots. This is joint work with John Carney.