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Christine Mennicke, NC State, “Methods for modeling cell proliferation and differentiation patterns in the neurogenesis-to-gliogenesis switch”
February 6, 2017 | 4:00 pm EST
Radial glial progenitors follow patterns of proliferation and differentiation to produce neurons and glia in the developing brain. The cells first undergo neurogenesis, producing neurons in a fairly deterministic manner, and then a portion of the cell population switches to producing glia. This neurogenesis-to-gliogenesis switch (NGS) and the patterns of cell division in gliogenesis are not yet undestood to be deterministic or stochastic. I will discuss methods from papers that have explored cell division patterns, then explain how these methods can be used to analyze to data we have from the NGS. Additionally, I will examine different approaches for creating cell division models.