We study a critical case of Coagulation-Fragmentation equations with multiplicative coagulation kernel and constant fragmentation kernel. Our method is based on the study of viscosity solutions to a new singular Hamilton-Jacobi equation, which results from applying the Bernstein transform to the original Coagulation-Fragmentation equation. Our results include wellposedness, regularity and long-time behaviors of viscosity solutions to the Hamilton-Jacobi equation in certain regimes, which have implications to wellposedness and long-time behaviors of mass-conserving solutions to the Coagulation-Fragmentation equation. These solve partly a long standing open problem in the field. Joint work with Truong-Son Van (CMU).