A significant challenge in the development of drugs to treat central nervous system (CNS) disorders is to attain sufficient delivery of antibodies across blood-brain barriers (BBB). Since not all antibodies can pass through BBB, it is crucial to understand antibody exposure in the CNS quantitatively to construct drug characteristics and identify proper dosing regimens. We…

Variance-based global sensitivity analysis (GSA) can provide a wealth of information when applied to complex models. A well-known Achilles' heel of this approach is its computational cost which often renders it unfeasible in practice. An appealing alternative is to analyze instead the sensitivity of a surrogate model with the goal of lowering computational costs while…

Galerkin reduced-order models (ROMs) approximate computational fluid simulations by reducing snapshot data to a basis of proper orthogonal decomposition (POD) modes and solving for modal coefficients with ordinary differential equations. Galerkin ROMs reduce computational cost and can approximate flows with alternate Reynolds numbers, while parametric reduced order models allow adjustment of other system parameters. However,…

Given the inability to directly observe the conditions of a fault line, inversion of parameters describing them has been a subject of practical interest for the past couple of decades. To resolve this under a linear elasticity forward model, we consider Bayesian inference in the infinite dimensional setting given some surface displacement measurements, resulting in…