Radial glial progenitors follow patterns of proliferation and differentiation to produce neurons and glia in the developing brain. The cells first undergo neurogenesis, producing neurons in a fairly deterministic manner, and then a portion of the cell population switches to producing glia. This neurogenesis-to-gliogenesis switch (NGS) and the patterns of cell division in gliogenesis are…

For models with high-dimensional input spaces, constructing accurate response surfaces can be prohibitively expensive. Additionally, the high-dimensionality of the parameter spaces can impact the computational cost of a parameter investigation. Using an active subspace construction, we can efficiently approximate complex models by constructing low-order response surfaces based on a smaller subspace of the high-dimensional parameter…