Radial glial progenitors follow patterns of proliferation and differentiation to produce neurons and glia in the developing brain. The cells first undergo neurogenesis, producing neurons in a fairly deterministic manner, and then a portion of the cell population switches to producing glia. This neurogenesis-to-gliogenesis switch (NGS) and the patterns of cell division in gliogenesis are…

For models with high-dimensional input spaces, constructing accurate response surfaces can be prohibitively expensive. Additionally, the high-dimensionality of the parameter spaces can impact the computational cost of a parameter investigation. Using an active subspace construction, we can efficiently approximate complex models by constructing low-order response surfaces based on a smaller subspace of the high-dimensional parameter…

Nik Bravo: Title: Data-Driven Model Development and Feedback Control Design for PZT Bimorph Actuators Abstract: In the talk, we discuss the development of a high-fidelity and surrogate model for a PZT bimorph used as an actuator for micro-air vehicles including Robobee. The models must quantify the nonlinear, hysteretic, and rate-dependent behavior inherent to PZT in…

Borosilicate glass is the material predominately used for encasing carbon fiber (CF) microelectrodes for fast-scan cyclic voltammetry (FSCV) experiments. These capillaries insulate unexposed CF from the surrounding environment, while leaving a 150-200 um exposed CF tip in vivo that allows for electrochemical measurements of neurotransmitters. However, borosilicate glass commonly breaks during implantation; this can leave…