Jamie Nosbisch, NC State, Feedback Loops at the Level of Lipid Metabolism Enhance Sensitivity and Robustness in Models of Chemotactic Gradient Sensing
Jamie Nosbisch, NC State, Feedback Loops at the Level of Lipid Metabolism Enhance Sensitivity and Robustness in Models of Chemotactic Gradient Sensing
In fibroblasts responding to gradients of platelet-derived growth factor (PDGF), an important chemoattractant in development and wound healing, signaling through the phospholipase C (PLC)/protein kinase C (PKC) pathway proved necessary for chemotaxis, whereas pathways that collaborate to activate the Arp2/3 complex were found to be dispensable. PKC is activated through its binding to the lipid…