Postural Orthostatic Tachycardia Syndrome (POTS) is characterized by an increase of heart rate of 30 beats per minute (40 bpm in patients aged 12-19 years) upon a postural change, combined with the presence of orthostatic symptoms. In addition to these criteria, recent studies have shown that POTS patients exhibit large low frequency ~0.1 Hz heart…

The emerging single-cell and spatial genomics techniques allow us to elucidate the governing rules of multicellular systems with unprecedented resolution and depth. These datasets are often high-dimensional, complex, and heterogeneous. Mathematical tools are needed to extract biological insights from such data. In this talk, we will discuss several mathematical and machine learning methods for exploring…

Dr. Timsina's Talk: Identifiability and optimal control analysis of HIV infection and opioid addiction model. Abstract: In a compartmental model of HIV infection and opioid addiction, dynamics such as equilibria, basic reproduction number, and invasion numbers are presented. Identifiability and estimation of the parameters of the model are highlighted. Moreover, the effect of four distinct controls such…