Jamie Nosbisch, NC State, Feedback Loops at the Level of Lipid Metabolism Enhance Sensitivity and Robustness in Models of Chemotactic Gradient Sensing
Cox 306In fibroblasts responding to gradients of platelet-derived growth factor (PDGF), an important chemoattractant in development and wound healing, signaling through the phospholipase C (PLC)/protein kinase C (PKC) pathway proved necessary for chemotaxis, whereas pathways that collaborate to activate the Arp2/3 complex were found to be dispensable. PKC is activated through its binding to the lipid…