Radial glial progenitors follow patterns of proliferation and differentiation to produce neurons and glia in the developing brain. The cells first undergo neurogenesis, producing neurons in a fairly deterministic manner, and then a portion of the cell population switches to producing glia. This neurogenesis-to-gliogenesis switch (NGS) and the patterns of cell division in gliogenesis are…

For models with high-dimensional input spaces, constructing accurate response surfaces can be prohibitively expensive. Additionally, the high-dimensionality of the parameter spaces can impact the computational cost of a parameter investigation. Using an active subspace construction, we can efficiently approximate complex models by constructing low-order response surfaces based on a smaller subspace of the high-dimensional parameter…

Nik Bravo: Title: Data-Driven Model Development and Feedback Control Design for PZT Bimorph Actuators Abstract: In the talk, we discuss the development of a high-fidelity and surrogate model for a PZT bimorph used as an actuator for micro-air vehicles including Robobee. The models must quantify the nonlinear, hysteretic, and rate-dependent behavior inherent to PZT in…

Borosilicate glass is the material predominately used for encasing carbon fiber (CF) microelectrodes for fast-scan cyclic voltammetry (FSCV) experiments. These capillaries insulate unexposed CF from the surrounding environment, while leaving a 150-200 um exposed CF tip in vivo that allows for electrochemical measurements of neurotransmitters. However, borosilicate glass commonly breaks during implantation; this can leave…

Poro-elastic and poro-visco-elastic models describe fluid flow through porous, deformable media. They are relevant in many applications in bioengineering and medicine, such as tissue perfusion and fluid flow inside cartilages and bones. In this talk, I will discuss the application of these models specifically to optical perfusion and its relation to glaucoma, as well as…