Chromatin structure tightly regulates gene expression and epigenetic processes. The nuclear environment is complex, featuring tension exerted by force-generating proteins and molecular crowding modulated by different ionic concentrations. Understanding the impact of these factors on chromatin structure is crucial for elucidating the molecular mechanisms of chromatin accessibility and organization. However, it is unclear how chromatin…

Zoom Meeting: https://ncsu.zoom.us/j/93046132033?pwd=dkZiTjlKazgzK2Q3aXJra1g2R1Q0dz09 Meeting ID: 930 4613 2033 Passcode: 075251

Recently, single-cell transcriptomics has provided a powerful approach to investigate cellular properties in unprecedented resolution. However, given a small number of temporal snapshots of single-cell transcriptomics, how to connect them to obtain their collective dynamical information remains an unexplored area. One major challenge to connecting temporal snapshots is that cells measured at one temporal point…

Zoom Meeting: https://ncsu.zoom.us/j/93046132033?pwd=dkZiTjlKazgzK2Q3aXJra1g2R1Q0dz09 Meeting ID: 930 4613 2033 Passcode: 075251

All BMA seminars have a virtual option with the following Zoom Link: https://ncsu.zoom.us/j/93046132033?pwd=dkZiTjlKazgzK2Q3aXJra1g2R1Q0dz09 Meeting ID: 930 4613 2033 Passcode: 075251

All BMA seminars have a virtual option with the following Zoom Link: https://ncsu.zoom.us/j/93046132033?pwd=dkZiTjlKazgzK2Q3aXJra1g2R1Q0dz09 Meeting ID: 930 4613 2033 Passcode: 075251

Mean-field game (MFG) systems provide a powerful framework for modeling the collective behavior of multi-agent systems with diverse applications, including those in biological populations. However, unknown parameters pose challenges. In this work, we tackle an inverse problem, recovering MFG parameters from limited, noisy boundary observations. Despite the problem's ill-posed nature, we aim to efficiently retrieve…

As with weather, there is a limit to how far into the future we can accurately forecast the future course of epidemics. Yet, we often need to make plans further into the future than we can reasonably forecast, and in many cases our actions themselves will change the course of an epidemic. One solution to this conundrum is the construction of "planning scenarios" where we project the likely course of an epidemic well beyond the…

This talk will focus on point-cloud data, their analysis and biological applications in which they naturally arise. In particular, I will introduce "optimal transport", which has evolved as one of the major frameworks to meaningfully compare point-cloud data and explain how it can be incorporated into classical machine learning algorithms for further downstream analysis. This…

Speaker's website Zoom Link

This talk will be in person in Cox 306 where snacks and refreshments will be provided, there will also be a virtual option for those who cannot attend in person. Speaker's website Zoom Link

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Gene co-expression graphs are a rich source of information, revealing critical insights into cellular functions, states, and activities. Yet, extracting meaningful signals from these graphs presents a formidable challenge. This complexity arises due to the presence of multiple, overlapping sources of information and the inherent noise, which is particularly pronounced in data derived from single-cell…

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Biology is defined by non-linear reactions caused by numerous molecular components interacting inside living cells. The complexity of such systems has limited classical experimental approaches in their capacity to measure living biological networks. This talk will explore how new computational tools derived from artificial intelligence are currently applied to study complex biological networks in living…

Malaria is a deadly infectious disease causing over 200 million cases and over half a million deaths each year. It is transmitted through the bite of an infectious Anopheles mosquito. Control methods, primarily focused on affecting the ability of the mosquito to bite or transmit the disease by employing insecticides, have reduced the impact of…