Kamala Dadashova, NC State, Parameter subset selection for a mathematical model of antibody therapies for neurological diseases
SAS 1220A significant challenge in the development of drugs to treat central nervous system (CNS) disorders is to attain sufficient delivery of antibodies across blood-brain barriers (BBB). Since not all antibodies can pass through BBB, it is crucial to understand antibody exposure in the CNS quantitatively to construct drug characteristics and identify proper dosing regimens. We…