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Cox 306

January 2017

Andrea Arnold, NC State, “Bayesian filtering for time-varying parameter estimation in biological models”

January 19, 2017 | 4:20 pm - 5:20 pm EST

Many applications in the life sciences involve unknown system parameters that must be estimated using little to no prior information. In addition, these parameters may be time-varying and possibly subject to structural characteristics such as periodicity. We show how nonlinear…

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February 2017

Boris Gutkin, École Normale Supérieure, Paris, “Dynamics of dopamine neuron firing in normal and drug-modulated conditions”

February 21, 2017 | 4:20 pm - 5:20 pm EST

Dopaminergic neurons in the ventral tegmental area play a key role in signalling motivational information. Modulation of this signalling by drugs is also key to the development of addiction. These neurons have several firing modes ranging from periodic low frequency…

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Deborah Shutt, Colorado School of Mines, “Understanding the impact of at risk populations for analyzing Zika virus in Central and South American countries”

February 23, 2017 | 4:20 pm - 5:20 pm EST

April 2017

Laura Storch, University of New Hampshire, “Chaos in ecology: A theoretical approach and a direct application using examples from fisheries”

April 4, 2017 | 4:20 pm - 5:20 pm EDT

Part 1: A theoretical approachChaotic dynamics have been directly detected in ocean dwelling species, and asymmetrical advective dispersal is the dominant dispersal mechanism in the ocean. Therefore, we must better our understanding of chaotic population dynamics under the influence of…

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Nick Hill and Xiaoyu Luo, University of Glasgow, “Aspects of the cardiovascular system”

April 6, 2017 | 4:20 pm - 5:20 pm EDT

Aspects of the cardiovascular system:(i) coupling between the left ventricle and systemic arteries, and (ii) arterial dissection. Two topics in mathematical and computational modelling of the systemic arterial circulation will be discussed. First, an immersed boundary model of the left…

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June 2017

Tom Britton, Stockholm University, “Statistical challenges when analysing emerging epidemic outbreaks”

June 15, 2017 | 10:30 am - 11:30 am EDT

New infectious disease outbreaks have great impact on communities over the world, as recently manifested by the Ebola outbreak. An important statistical task is then to predict the future scenario with and with out preventive measures. In the current talk…

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September 2017

Garrett Nieddu, Montclair State University, Rare Events in Stochastic Population Models

September 29, 2017 | 2:00 pm - 3:00 pm EDT

Noise can play a critical role in a wide array of physical and biological dynamical systems. The noise may be internal or external to the system. Internal noise is intrinsic to the system itself, and in stochastic population models, arises…

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October 2017

Tim David, University of Canterbury, NZ, The Dynamics of Coupled Cells: From the Discrete to the Continuous

October 12, 2017 | 4:20 pm - 5:30 pm EDT

Why do atherosclerotic plaques only occur at specific sites in the arteries? Does the surface geometry of the brain affect the way waves move through the cortex? These questions and many others in the physiological sphere contain implicitly a real difficulty for modellers. How…

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Casey Diekman, New Jersey Inst. Tech., Circadian regulation of gene expression and electrical activity in neurons and cardiomyocytes

October 17, 2017 | 4:20 pm - 5:20 pm EDT

Circadian (~24-hour) rhythms offer one of the clearest examples of the interplay between different levels of nervous system organization, with dynamic changes in gene expression leading to daily rhythms in neural activity, physiology, and behavior. The main output signal of…

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Christina Battista and Zackary Kenz, DILIsym Services Inc., Quantitative Systems Toxicology: Mathematical Modeling Applications in DILIsym

October 24, 2017 | 4:20 pm - 5:20 pm EDT

The pharmaceutical industry has increasingly embraced mathematical modeling as a method to predict drug-body interactions. In particular, issues of drug toxicity and drug-drug interactions impact the drug development and approval process. Initially begun as a private-public partnership, DILIsym Services is…

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November 2017

Laura Potter, Global Head of Computational Biology, Syngenta, Helping feed the world with innovative agricultural products: Opportunities for computational biology

November 14, 2017 | 4:20 pm - 5:20 pm EST

As the world’s rapidly growing population is driving ever increasing demand for food, feed and fuel, we are faced with the challenge to grow higher-yielding crops with less water and fewer inputs.  Agriculture companies are focused on meeting these needs…

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March 2018

Amanda Laubmeier, NC State, A Model-Driven Approach to Experimental Validation of Predator-Prey Dynamics in a System of Terrestrial Arthropods

March 20, 2018 | 10:00 am - 12:00 pm EDT

October 2018

Jamie Nosbisch, NC State, Feedback Loops at the Level of Lipid Metabolism Enhance Sensitivity and Robustness in Models of Chemotactic Gradient Sensing

October 2, 2018 | 4:20 pm - 5:20 pm EDT

In fibroblasts responding to gradients of platelet-derived growth factor (PDGF), an important chemoattractant in development and wound healing, signaling through the phospholipase C (PLC)/protein kinase C (PKC) pathway proved necessary for chemotaxis, whereas pathways that collaborate to activate the Arp2/3…

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Suzanne M. O’Regan, North Carolina A&T State University, Early warning signals of critical transitions: new theoretical directions

October 9, 2018 | 4:20 pm - 5:20 pm EDT

Anticipating abrupt changes in ecosystem state is key for ecosystem management and preservation. Detailed knowledge of ecological mechanisms behind a critical transition is often difficult to attain, and the theory of resilience - assessment of the ability of a system…

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Nicolas Buchler, NC State, Evolution and interaction of oscillators in a noisy cell

October 16, 2018 | 4:20 pm - 5:20 pm EDT

Gene expression is a biochemical process driven by the chance collisions of molecules, which can result in strong stochastic signatures and cell-to-cell variability in gene network dynamics (e.g. oscillation). Biological oscillators co-exist in the same cell and can interact directly…

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November 2018

Marcella Noorman, NC State, Analysis of Fluid Flow Models with Biological Applications

November 2, 2018 | 10:00 am - 1:00 pm EDT

January 2019

An Introduction to Data Manipulation in R Studio

January 29, 2019 | 4:20 pm - 5:20 pm EST

This semester the Biomathematics GSA will be hosting student led tutorials on a variety of topics. The goal of these tutorials is to help graduate students develop computational tools. This week will cover data manipulation using R Studio. If you…

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April 2019

Jacek Brodzki, Centre for Geometry, Topology, and Applications, Southampton, Persistence in action: quantifying the topology of lungs

April 16, 2019 | 4:20 pm - 5:20 pm EDT

Topology is dedicated to the study of shapes, and its starting point is an easy-sounding question: How can I tell if two objects are similar? While humans are very adept at distinguishing a large variety of shapes, it is not…

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November 2019

Renee Brady, NC State, Forecasting Cancer: Predicting Individual Responses to Intermittent Androgen Deprivation Therapy in Prostate Cancer

November 21, 2019 | 4:30 pm - 5:30 pm EST

Intermittent androgen deprivation therapy (IADT) is an attractive treatment approach for biochemically recurrent prostate cancer (PCa), whereby cycling treatment on and off has been shown to limit toxicities and reduce cumulative dose. While IADT has been shown to delay the…

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