Events
Biomathematics Seminar
- Events
- Biomathematics Seminar
Laura Storch, University of New Hampshire, “Chaos in ecology: A theoretical approach and a direct application using examples from fisheries”
Cox 306Part 1: A theoretical approachChaotic dynamics have been directly detected in ocean dwelling species, and asymmetrical advective dispersal is the dominant dispersal mechanism in the ocean. Therefore, we must better our understanding of chaotic population dynamics under the influence of a unidirectional current. Here, we examine a spatially explicit, density-dependent population in a unidirectional current,…
Nick Hill and Xiaoyu Luo, University of Glasgow, “Aspects of the cardiovascular system”
Cox 306Aspects of the cardiovascular system:(i) coupling between the left ventricle and systemic arteries, and (ii) arterial dissection. Two topics in mathematical and computational modelling of the systemic arterial circulation will be discussed. First, an immersed boundary model of the left ventricle (LV) is coupled to a structured tree model of the systemic arteries. There is…
Tom Britton, Stockholm University, “Statistical challenges when analysing emerging epidemic outbreaks”
Cox 306New infectious disease outbreaks have great impact on communities over the world, as recently manifested by the Ebola outbreak. An important statistical task is then to predict the future scenario with and with out preventive measures. In the current talk we will investigate such analyses and see how it can be improved. The main catch…
Garrett Nieddu, Montclair State University, Rare Events in Stochastic Population Models
Cox 306Noise can play a critical role in a wide array of physical and biological dynamical systems. The noise may be internal or external to the system. Internal noise is intrinsic to the system itself, and in stochastic population models, arises due to the random interactions of discrete agents in the system. On the other hand,…
Tim David, University of Canterbury, NZ, The Dynamics of Coupled Cells: From the Discrete to the Continuous
Cox 306Why do atherosclerotic plaques only occur at specific sites in the arteries? Does the surface geometry of the brain affect the way waves move through the cortex? These questions and many others in the physiological sphere contain implicitly a real difficulty for modellers. How do we contend with the multiple scale lengths. Plaques are quite large compared to cells making…
Casey Diekman, New Jersey Inst. Tech., Circadian regulation of gene expression and electrical activity in neurons and cardiomyocytes
Cox 306Circadian (~24-hour) rhythms offer one of the clearest examples of the interplay between different levels of nervous system organization, with dynamic changes in gene expression leading to daily rhythms in neural activity, physiology, and behavior. The main output signal of the master circadian clock in mammals has long been believed to be a simple day/night…
Christina Battista and Zackary Kenz, DILIsym Services Inc., Quantitative Systems Toxicology: Mathematical Modeling Applications in DILIsym
Cox 306The pharmaceutical industry has increasingly embraced mathematical modeling as a method to predict drug-body interactions. In particular, issues of drug toxicity and drug-drug interactions impact the drug development and approval process. Initially begun as a private-public partnership, DILIsym Services is the leading software platform to help inform issues relating to drug-induced liver injury (DILI) by…
Laura Potter, Global Head of Computational Biology, Syngenta, Helping feed the world with innovative agricultural products: Opportunities for computational biology
Cox 306As the world’s rapidly growing population is driving ever increasing demand for food, feed and fuel, we are faced with the challenge to grow higher-yielding crops with less water and fewer inputs. Agriculture companies are focused on meeting these needs by delivering innovative products and technologies into the marketplace that improve crop performance. This requires…
Jamie Nosbisch, NC State, Feedback Loops at the Level of Lipid Metabolism Enhance Sensitivity and Robustness in Models of Chemotactic Gradient Sensing
Cox 306In fibroblasts responding to gradients of platelet-derived growth factor (PDGF), an important chemoattractant in development and wound healing, signaling through the phospholipase C (PLC)/protein kinase C (PKC) pathway proved necessary for chemotaxis, whereas pathways that collaborate to activate the Arp2/3 complex were found to be dispensable. PKC is activated through its binding to the lipid…
Suzanne M. O’Regan, North Carolina A&T State University, Early warning signals of critical transitions: new theoretical directions
Cox 306Anticipating abrupt changes in ecosystem state is key for ecosystem management and preservation. Detailed knowledge of ecological mechanisms behind a critical transition is often difficult to attain, and the theory of resilience - assessment of the ability of a system to withstand disturbances - provides a pathway to circumvent this problem. Loss of system resilience…
Nicolas Buchler, NC State, Evolution and interaction of oscillators in a noisy cell
Cox 306Gene expression is a biochemical process driven by the chance collisions of molecules, which can result in strong stochastic signatures and cell-to-cell variability in gene network dynamics (e.g. oscillation). Biological oscillators co-exist in the same cell and can interact directly or indirectly through shared resources. Our lab uses modeling and experiments to understand how these…
Ben Randall, NC State, Cardiovascular and neurological modeling in response to the Valsalva maneuver
The Valsalva maneuver (VM) is a quick, noninvasive, clinical procedure with a variety of uses. In particular, the VM can aid in the diagnosis of autonomic nervous system dysfunction. The VM induces changes in blood pressure, which reflexively induces a neural signaling cascade to adjust heart rate, heart contractility, peripheral vascular resistance, and venous compliance.…
An Introduction to Data Manipulation in R Studio
Cox 306This semester the Biomathematics GSA will be hosting student led tutorials on a variety of topics. The goal of these tutorials is to help graduate students develop computational tools. This week will cover data manipulation using R Studio. If you are interested in participating please bring a laptop with the necessary software (R and R…
An Introduction to Data Visualization in R using ggplot
This semester the Biomathematics GSA will be hosting student led tutorials on a variety of topics. The goal of these tutorials is to help graduate students develop computational tools. This week will cover data visualization using R Studio with the ggplot package. If you are interested in participating please bring a laptop with the necessary…
Introduction to R Shiny: presenting results with an interactive web application
This semester the Biomathematics GSA will be hosting student led tutorials on a variety of topics. The goal of these tutorials is to help graduate students develop computational tools. This week will cover the development of interactive web applications using R Studio with the shiny package. If you are interested in participating please bring a…
Jacek Brodzki, Centre for Geometry, Topology, and Applications, Southampton, Persistence in action: quantifying the topology of lungs
Cox 306Topology is dedicated to the study of shapes, and its starting point is an easy-sounding question: How can I tell if two objects are similar? While humans are very adept at distinguishing a large variety of shapes, it is not always easy to say precisely what makes this object similar to or distinct from that…
Renee Brady, NC State, Forecasting Cancer: Predicting Individual Responses to Intermittent Androgen Deprivation Therapy in Prostate Cancer
Cox 306Intermittent androgen deprivation therapy (IADT) is an attractive treatment approach for biochemically recurrent prostate cancer (PCa), whereby cycling treatment on and off has been shown to limit toxicities and reduce cumulative dose. While IADT has been shown to delay the development of treatment resistance, underlying mechanisms and actionable biomarkers are required to accurately predict when…
Sarah Olson, Worcester Polytechnic Institute, Modeling the dynamics of centrosome movement
Cox 306The mitotic spindle is a complex, dynamic machine important for cell division. The spindle is composed of a network of microtubules and motor proteins that generate forces to form a bipolar spindle, with each pole organized around a single centrosome. Disruption in force generating activities through protein depletions or alterations to centrosome number, alter spindle…
Rayanne Luke, University of Delaware, Parameter Identification for Tear Film Thinning and Breakup
ZoomMillions of Americans experience dry eye syndrome, a condition that decreases quality of vision and causes ocular discomfort. A phenomenon associated with dry eye syndrome is tear film breakup (TBU), or the formation of dry spots on the eye. The dynamics of the tear film can be studied using fluorescence imaging. Many parameters affecting tear…